Scientific Publications

Publications on non-replicating technolgy

Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig & Lukas Flatz (2021). Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nature Communications

Michael Schwendinger, Georges Thiry, Beatrice De Vos, Geert Leroux-Roels, Jacques Bruhwyler, Ariane Huygens,... & Anders E Lilja (2020). A Randomized Dose-Escalating Phase I Trial of a Replication-Deficient Lymphocytic Choriomeningitis Virus Vector-Based Vaccine Against Human Cytomegalovirus. The Journal of Infectious Diseases, jiaa121.

Bernstein, D. I. (2017). Congenital cytomegalovirus: a “now” problem—no really, now. Clinical and Vaccine Immunology, 24(1), e00491-16. PubMed

MacMaster, P. P., Shields, J. L., Alayo, Q. A., Cabral, C., Jimenez, J., Mondesir, J., ... & Provine, N. M. (2017). Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. Vaccine, 35(1), 1-9. PubMed

Schleiss, M. R., Berka, U., Watson, E., Aistleithner, M., Kiefmann, B., Mangeat, B., ... & Zabeli, J. C. (2017). Additive protection against congenital cytomegalovirus conferred by combined glycoprotein B/pp65 vaccination using a lymphocytic choriomeningitis virus vector. Clinical and Vaccine Immunology, 24(1), e00300-16. PubMed

Wingerath, J., Ostroumov, D., Woller, N., Manns, M. P., Pinschewer, D. D., Orlinger, K., ... & Wirth, T. C. (2017). Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations. Molecular Therapy, 25(11), 2533-2545. PubMed

Cardin, R. D., Bravo, F. J., Pullum, D. A., Orlinger, K., Watson, E. M., Aspoeck, A., ... & Bernstein, D. I. (2016). Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. Vaccine, 34(17), 1993-1999. PubMed

Flatz, L., Cheng, C., Wang, L., Foulds, K., Ko, S. Y., Kong, W. P., ... & Asmal, M. (2012). Gene-based vaccination with a mis-matched envelope protects against simian immunodeficiency virus infection in non-human primates. Journal of virology, JVI-00599. PubMed

Flatz, L., Hegazy, A. N., Bergthaler, A., Verschoor, A., Claus, C., Fernandez, M., ... & Van Den Broek, M. (2010). Development of replication-defective lymphocytic choriomeningitis virus vectors for the induction of potent CD8+ T cell immunity. Nature medicine, 16(3), 339. PubMed

Publications on replicating technology

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Klaus Orlinger, Henning Lauterbach, Sarah Schmidt, Kia Katchar, Xiaoping Qing, Corinne Iacobucci, Andy Hwang, Katia Schlienger, Ursula Berka, Josipa Raguz, Sarah Ahmadi-Erber, Timo Schippers, Felix Stemeseder, Daniel D. Pinschewer and Igor Matushansky (2021). Development and Characterization of a Novel Non-Lytic Cancer Immunotherapy Using a Recombinant Arenavirus Vector Platform. frontiers in Oncology

Sandra S. Ring, Jovana Cupovic, Lucas Onder, Mechthild Lütge, Christian Perez-Shibayama, Cristina Gil-Cruz, Elke Scandella, Angelina De Martin, Urs Mörbe, Fabienne Hartmann, Robert Wenger, Matthias Spiegl, Andrej Besse, Weldy V. Bonilla, Felix Stemeseder, Sarah Schmidt, Klaus K. Orlinger, Philippe Krebs, Burkhard Ludewig & Lukas Flatz (2021). Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nature Communications

Ring, S.S., Cupovic, J., Onder, L., ... Krebs, P. Ludewig, B., & Flatz, L. (2021). Viral vector-mediated reprogramming of the fibroblastic tumor stroma sustains curative melanoma treatment. Nat Commun 12, 4734 (2021). Nature

Bonilla, W., Kirchhammer, N., Marx, A., ... Orlinger, K., Zippelius, A., & Pinschewer, D. (2021). Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack. journal.ppat.100209. Cell Reports Medicine

Sarah Schmidt, Weldy V. Bonilla, Andrea Reiter, Felix Stemeseder, Theresa Kleissner, Daniel Oeler, Ursula Berka,... & Klaus K. Orlinger (2020). Live-attenuated lymphocytic choriomeningitis virus-based vaccines for active immunotherapy
of HPV16-positive cancer. OncoImmunology

Page, N., Klimek, B., De Roo, M., Steinbach, K., Soldati, H., Lemeille, S., ... & Lingner, T. (2018). Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells. Immunity, 48(5), 937-950. PubMed

Kallert, S. M., Darbre, S., Bonilla, W. V., Kreutzfeldt, M., Page, N., Müller, P., ... & Löhning, M. (2017). Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy. Nature communications, 8, 15327. PubMed

Publications on Key Features of Arenaviruses

Sommerstein, R., Flatz, L., Remy, M., Malinge, P., Magistrelli, G., Fischer, N., ... & Pinschewer, D. (2015). Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection. journal.ppat.1005276. PubMed

Bonilla, W., Fröhlich, A., Senn, K., Kallert, S.,Fernandez, M., Johnson, S., ... & Pinschewer, D. (2012). The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses. Science 335(6071), 984. PubMed